Directed Random Walk Methods For Identifying Informative Cancer Genes


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This book describes cancer classifications in bioinformatics research as offered by the advancement in diagnosis. Integration of pathway data into microarray analysis should be done to reduce the complexity of cancer analysis. Directed Random Walk (DRW) method is one of the pathway-based microarray analyses. This method can infer a more robust pathway activity with greater reproducible power between normal and diseased samples. To identify the informative cancer genes in pathway activities and provide higher classification accuracy, this book proposes and describes a modified DRW method (termed DRW+). The book also contains a comprehensive description of the datasets used and flowcharts of the methods.

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